Table 2.

The regulated signaling pathways of SHP2 involved in inflammatory diseases

Disease	Cell type	Signaling pathway	References
SLE	T cell	ERK-IFN-γ-IL-17A/F	40
Psoriasis	Macrophage	TLR7-NF-κB	91
	Neutrophil	ERK-NETosis	93
Systemic sclerosis	Fibroblast	TGF-β-JAK-STAT3	55
Contact dermatitis	T cell	AKT/STAT3	95
Osteoarthritis	Chondrocyte	DOK1-UPP1-Urdine	100
		Wnt/β-Catenin	35
		MAPK-NF-κB	35
Rheumatoid arthritis	Osteoblast	RUNX2/OSTERIX	102,103
	T cell	CD31-ZAP70.	97
	Fibroblast	IL17A-STAT3	96
Ankylosing spondylitis	Chondrocyte Osteoblast	BMP6/pSmad1/5	104
Parkinson’s disease	Neuronal cell	Parkin-Mitophagy	38
		FAK-LRRK2	69
		DIR-ERK	71–73
Alzheimer’s disease	Microglial cell	JAK/STAT	70
	Neuronal cell	cKit- Aβ	76
		Tau	77
Gastric inflammation	Epithelial cell	CagA-IFNγ/STAT1	42
		ERK/MAPK	43
		JAK/STAT-IL-6	43
IBD	Macrophage	IL-10/STAT3	44
		JAK2/STAT3	45
		SIRPα/CD47/SHP2/IL4/IL13	47
	T cell	STAT1-IFN-γ	46
Asthma	Fibroblast	IL6-STAT3	55,56
	Neutrophil	RhoA	53
Pulmonary fibrosis	Epithelial cell	TTF1-ABCA3	61
		FGF/GAB/ERK	61
	Fibroblast	STAT3-SOCS3	56
	Macrophage	IL4-JAK1-STAT 6	60
	Macrophage	M2 polarization	60
Lung inflammation		TGF-β-MMP12	57
	Epithelial cell	EGFR/Gab/MAPK	63
T1DM	T cell	mTOR/PD-1	83
	Macrophage	JAK-STAT-IFNI	82
T2DM	Macrophage	RAS-ERK-M2 polarization	84
		MAPK-endocytosis	85
		Akt/ERK	86,87
		IL-18	88
Non-alcoholic steatohepatitis	Hepatocyte	ROS-cJUN	107
Hepatic steatosis	Macrophage	ERK signaling	88