Table 4. Association Between Parathyroidectomy and Outcomesa.
| HR (95% CI) | P value | |
|---|---|---|
| Any fracture | ||
| Adjusted for time since diagnosis, current age, sex, and calendar year | 0.83 (0.75-0.93) | .001 |
| Further adjusted for Charlson Comorbidity Index and previous fracture | 0.84 (0.76-0.94) | .003 |
| Major osteoporotic fracture | ||
| Adjusted for time since diagnosis, current age, sex, and calendar year | 0.82 (0.71-0.94) | .004 |
| Further adjusted for Charlson Comorbidity Index and previous fracture | 0.83 (0.72-0.95) | .007 |
| Hip fracture | ||
| Adjusted for time since diagnosis, current age, sex, and calendar year | 0.78 (0.61-0.98) | .04 |
| Further adjusted for Charlson Comorbidity Index and previous fracture | 0.80 (0.63-1.02) | .07 |
| Injurious fall | ||
| Adjusted for time since diagnosis, current age, sex, and calendar year | 0.83 (0.74-0.92) | <.001 |
| Further adjusted for Charlson Comorbidity Index and previous injurious fall | 0.85 (0.76-0.95) | .003 |
| Any CVE | ||
| Adjusted for time since diagnosis, current age, sex, and calendar year | 0.84 (0.73-0.97) | .02 |
| Further adjusted for Charlson Comorbidity Index and previous CVE | 0.87 (0.75-1.00) | .05 |
| Acute myocardial infarction | ||
| Adjusted for time since diagnosis, current age, sex, and calendar year | 0.84 (0.68-1.04) | .10 |
| Further adjusted for Charlson Comorbidity Index and previous CVE | 0.87 (0.70-1.08) | .20 |
| Ischemic stroke | ||
| Adjusted for time since diagnosis, current age, sex, and calendar year | 0.90 (0.74-1.09) | .28 |
| Further adjusted for Charlson Comorbidity Index and previous CVE | 0.92 (0.76-1.12) | .30 |
| Kidney stone | ||
| Adjusted for time since diagnosis, current age, sex, and calendar year | 0.89 (0.76-1.06) | .19 |
| Further adjusted for Charlson Comorbidity Index and previous kidney stone | 0.77 (0.65-0.91) | .003 |
| Death overall | ||
| Adjusted for time since diagnosis, current age, sex, and calendar year | 0.59 (0.53-0.65) | <.001 |
| Further adjusted for Charlson Comorbidity Index | 0.64 (0.58-0.71) | <.001 |
| Cardiovascular-related death | ||
| Adjusted for time since diagnosis, current age, sex, and calendar year | 0.60 (0.50-0.71) | <.001 |
| Further adjusted for Charlson Comorbidity Index and previous CVE | 0.71 (0.59-0.85) | <.001 |
Abbreviations: CVE, cardiovascular event; HR, hazard ratio.
a
Parathyroidectomy was used as a time-dependent variable in the Poisson regression model, with adjustments for time since diagnosis, current age, sex, and calendar year in the primary models as well as outcome-specific additional adjustments as indicated.