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. 2022 May 20;12:839816. doi: 10.3389/fonc.2022.839816

Figure 4.

Figure 4

Vitamin D status is associated with LDH s.c. in advanced melanoma patients treated with BRAF/MEK and/or immune checkpoint inhibitors. During the complete OP, LDH s.c. was significantly lower (-170.826 U/l; p = 0.019) in patients with average 25(OH)D s.c. ≥10 ng/ml as compared to severely vitamin D-deficient individuals [average 25(OH)D s.c <10 ng/ml]. In general, an increase in average 25(OH)D s.c. of 1 ng/ml was associated with a significant reduction of LDH s.c. of 3.84 U/l (p = 0.034). Rounding error may occur. Number of patients may differ from total sample sizes due to missing data.