Fig. 10. A model scheme for steady state of chromatin motion.
Top: During cell cycle progression, genomic DNA quantity (blue line) doubles during replication accompanied by increasing nuclear volume (gray triangle). These nuclear changes do not affect local chromatin motion (steady-state chromatin motion, red line). On the other hand, chromatin motion transiently increases after perceived DNA damage, presumably for efficient repair process, and drops back to the original level when the damage is repaired or no longer detected (dashed line). Bottom: Local liquid-like chromatin motion (blue and yellow spheres in gray circles), which is mainly driven by thermal fluctuations, maintains a steady state during the cell cycle from G1 to S and then to G2. Five chromosomes are shown in different colors.