Table 2.

The correlation analysis between EZH2 and related immune cell genes and markers of immune cells in TIMER

Immune cell	Gene markers	None		Purity
		Cor	P-value	Cor	P-value
CD8 + T cell	CD8A	0.180	**	0.286	***
	CD8B	0.160	*	0.272	***
T cell	CD6	0.161	*	0.305	***
	CD3D	0.235	***	0.350	***
	CD3E	0.161	*	0.214	***
	SH2D1A	0.147	*	0.265	***
	TRAT1	0.141	*	0.267	***
	CD3G	0.226	***	0.324	***
	CD2	0.182	**	0.323	***
B cell	CD19	0.244	***	0.318	***
	FCRL2	0.173	**	0.303	***
	KIAA0125	0.118	0.023	0.226	***
	TNFRSF17	0.130	0.012	0.264	***
	SPIB	0.373	***	0.464	***
	PNOC	0.166	*	0.279	***
	CD79A	0.131	0.012	0.245	***
Monocyte	CD86	0.294	***	0.449	***
	CD115(CSF1R)	0.153	*	0.296	***
TAM	CD68	0.210	***	0.301	***
	IL10	0.220	***	0.335	***
M1 macrophage	IRF5	0.482	***	0.487	***
	COX2(PTGS2)	0.088	0.092	0.212	***
M2 macrophage	CD163	0.101	0.052	0.218	***
	MS4A4A	0.102	0.051	0.231	***
Neutrophils	FPR1	0.218	***	0.35	***
	SIGLEC5	0.271	***	0.402	***
	CSF3R	0.285	***	0.428	***
	FCGR3B	0.175	**	0.206	**
	CEACAM3	0.16	0.041	0.186	**
	CD116(ITGAM)	0.289	***	0.387	***
Dendritic cell	CCL13	0.137	*	0.196	**
	CD209	0.127	0.014	0.212	***
	HSD11B1	0.332	***	− 0.336	***
	HLA-DPB1	0.154	*	0.271	***
	HLA-DQB1	0.146	*	0.256	***
	HLA-DRA	0.167	*	0.287	***
	HLA-DPA1	0.158	*	0.283	***
	BCDA-1(CD1C)	0.114	0.029	0.207	**
	BDCA-4(NRP1)	0.263	***	0.291	***
	CD11c(ITGAX)	0.348	***	0.484	***
Natural killer cell	XCL2	0.17	**	0.258	***
	KIR2DL1	0.039	0.455	0.018	0.742
	KIR2DL3	0.168	*	0.205	**
	KIR2DL4	0.211	***	0.241	***
Mast cell	TPSB2	− 0.037	0.479	0.001	0.986
	HDC	− 0.149	*	− 0.121	0.025
Th1	IFN-γ(IFNG)	0.249	***	0.333	***
	TNF-α(TNF)	0.282	***	0.414	***
	STAT4	0.238	***	0.303	***
	STAT1	0.387	***	0.246	***
Th2	GATA3	0.172	**	0.309	***
	STAT6	0.193	**	0.179	**
	STAT5A	0.329	***	0.389	***
Tfh	BCL6	0.201	***	0.205	**
	IL21	0.147	*	0.188	**
Th17	STAT3	0.168	*	0.209	***
	IL17A	0.072	0.168	0.075	0.164
Effector T cell	CX3CR1	0.187	**	0.242	***
	FGFBP2	− 0.085	0.103	− 0.07	0.195
	FCGR3A	0.295	***	0.383	***
Effector memory T cell	PD-1 (PDCD1)	0.295	***	0.391	***
	DUSP4	0.256	***	0.363	***
Central memory T cell	CCR7	0.083	0.111	0.219	***
	SELL	0.196	**	0.308	***
	IL7R	0.093	0.073	0.201	**
Resident memory T cell	CD69	0.109	0.035	0.222	***
	ITGAE	0.279	***	0.280	***
	CXCR6	0.156	*	0.288	***
	MYADM	0.354	***	0.388	***
Exhausted T cell	TIM-3 (HAVCR2)	0.310	***	0.472	***
	TIGIT	0.262	***	0.385	***
	LAG3	0.287	***	0.332	***
	CXCL13	0.264	***	0.342	***
	LAYN	0.185	**	0.257	***
Resting treg T cell	FOXP3	0.191	**	0.262	***
	IL2RA	0.252	***	0.377	***
Effector treg T cell	CTLA4	0.296	***	0.404	***
	CCR8	0.383	***	0.479	***

Cor, R-value of Spearman correlation; Purity, tumor purity-adjusted correlation. None, correlation without adjustment. *P < 0.01; **P < 0.001; ***P < 0.0001