Table 3.
Immune cell | Gene markers | Tumor | Tumor-sum | Normal | Normal-sum | ||||
---|---|---|---|---|---|---|---|---|---|
Cor | P-value | Cor | P-value | Cor | P-value | Cor | P-value | ||
CD8 + T cell | CD8A | 0.2 | *** | 0.18 | ** | 0.71 | *** | 0.69 | *** |
CD8B | 0.15 | *** | 0.62 | *** | |||||
T cell | CD6 | 0.029 | 0.11 | 0.17 | * | 0.49 | ** | 0.71 | *** |
CD3D | 0.23 | *** | 0.65 | *** | |||||
CD3E | 0.13 | 0.01 | 0.59 | *** | |||||
SH2D1A | 0.13 | 0.011 | 0.68 | *** | |||||
TRAT1 | 0.034 | 0.51 | 0.65 | *** | |||||
CD3G | 0.24 | *** | 0.63 | *** | |||||
CD2 | 0.15 | * | 0.52 | ** | |||||
B cell | CD19 | 0.11 | 0.03 | 0.21 | *** | 0.39 | * | 0.36 | *** |
FCRL2 | 0.076 | 0.14 | 0.57 | *** | |||||
KIAA0125 | 0.15 | * | 0.53 | *** | |||||
TNFRSF17 | 0.094 | 0.071 | 0.6 | *** | |||||
SPIB | 0.14 | * | 0.43 | * | |||||
PNOC | 0.1 | 0.047 | 0.59 | *** | |||||
CD79A | 0.083 | 0.11 | 0.51 | ** | |||||
Monocyte | CD86 | 0.32 | *** | 0.27 | *** | 0.55 | *** | 0.55 | *** |
CD115(CSF1R) | 0.22 | *** | 0.49 | ** | |||||
TAM | CD68 | 0.23 | *** | 0.26 | *** | 0.53 | *** | 0.57 | *** |
IL10 | 0.21 | *** | 0.43 | * | |||||
M1 Macrophage | IRF5 | 0.44 | *** | 0.37 | *** | 0.44 | * | 0.44 | * |
COX2(PTGS2) | 0.035 | 0.5 | 0.27 | 0.055 | |||||
M2 Macrophage | CD163 | 0.16 | * | 0.12 | 0.017 | 0.38 | * | 0.47 | ** |
MS4A4A | 0.16 | * | 0.48 | ** | |||||
Neutrophils | FPR1 | 0.24 | *** | 0.35 | *** | 0.31 | 0.028 | 0.49 | ** |
SIGLEC5 | 0.27 | *** | 0.17 | 0.24 | |||||
CSF3R | 0.21 | *** | 0.5 | ** | |||||
FCGR3B | 0.03 | 0.56 | 0.32 | 0.021 | |||||
CEACAM3 | 0.15 | * | 0.25 | 0.078 | |||||
CD116(ITGAM) | 0.34 | *** | 0.69 | *** | |||||
Natural killer cell | XCL2 | 0.049 | 0.35 | 0.15 | * | 0.67 | *** | 0.6 | *** |
KIR2DL1 | 0.11 | 0.038 | 0.62 | *** | |||||
KIR2DL3 | 0.21 | *** | 0.22 | 0.12 | |||||
KIR2DL4 | 0.2 | *** | 0.32 | 0.025 | |||||
Dendritic cell | CCL13 | 0.065 | 0.22 | 0.068 | 0.19 | 0.41 | * | 0.64 | *** |
CD209 | 0.16 | * | 0.44 | * | |||||
HSD11B1 | − 0.22 | *** | 0.094 | 0.51 | |||||
HLA-DPB1 | 0.22 | *** | 0.58 | *** | |||||
HLA-DQB1 | 0.088 | 0.09 | 0.52 | *** | |||||
HLA-DRA | 0.22 | *** | 0.59 | *** | |||||
HLA-DPA1 | 0.2 | ** | 0.54 | *** | |||||
BCDA-1(CD1C) | 0.17 | ** | 0.63 | *** | |||||
BDCA-4(NRP1) | 0.28 | *** | 0.41 | * | |||||
CD11c(ITGAX) | 0.25 | *** | 0.5 | *** | |||||
Mast cell | TPSB2 | − 0.042 | 0.42 | 0.031 | 0.56 | 0.096 | 0.51 | − 0.097 | 0.5 |
HDC | − 0.059 | 0.26 | − 0.083 | 0.57 | |||||
Th1 | IFN-γ(IFNG) | 0.21 | *** | 0.29 | *** | 0.65 | *** | 0.84 | *** |
TNF-α(TNF) | 0.11 | .031 | 0.33 | 0.02 | |||||
STAT4 | 0.081 | 0.12 | 0.61 | *** | |||||
STAT1 | 0.21 | *** | 0.8 | *** | |||||
Th2 | GATA3 | 0.18 | ** | 0.29 | *** | 0.19 | 0.19 | 0.62 | *** |
STAT6 | 0.18 | ** | 0.57 | *** | |||||
STAT5A | 0.22 | *** | 0.69 | *** | |||||
Tfh | BCL6 | 0.1 | 0.054 | 0.17 | ** | 0.011 | 0.94 | 0.11 | 0.46 |
IL21 | 0.12 | 0.023 | 0.31 | 0.031 | |||||
Th17 | STAT3 | 0.29 | *** | 0.26 | *** | 0.11 | 0.44 | 0.2 | 0.16 |
IL17A | 0.0028 | 0.96 | 0.25 | 0.085 | |||||
Effector T cell | CX3CR1 | 0.14 | * | 0.27 | *** | 0.22 | 0.13 | 0.45 | * |
FGFBP2 | − 0.098 | 0.06 | 0.074 | 0.61 | |||||
FCGR3A | 0.29 | *** | 0.5 | *** | |||||
Effector memory T cell | PD-1 (PDCD1) | 0.22 | *** | 0.39 | *** | 0.73 | *** | 0.72 | *** |
DUSP4 | 0.29 | *** | 0.54 | *** | |||||
Central memory T cell | CCR7 | 0.064 | 0.22 | 0.12 | 0.023 | 0.58 | *** | 0.68 | *** |
SELL | 0.12 | 0.024 | 0.54 | *** | |||||
IL7R | 0.029 | 0.58 | 0.56 | *** | |||||
Resident memory T cell | CD69 | 0.039 | 0.46 | 0.28 | *** | 0.63 | *** | 0.64 | *** |
ITGAE | 0.23 | *** | 0.092 | 0.52 | |||||
CXCR6 | 0.14 | * | 0.44 | * | |||||
MYADM | 0.29 | *** | 0.24 | 0.1 | |||||
Exhausted T cell | TIM-3(HAVCR2) | 0.13 | 0.014 | 0.3 | *** | 0.53 | *** | 0.65 | *** |
PD-1 (PDCD1) | 0.22 | *** | 0.73 | *** | |||||
TIGIT | 0.22 | *** | 0.61 | *** | |||||
LAG3 | 0.2 | ** | 0.48 | ** | |||||
CXCL13 | 0.097 | 0.064 | 0.31 | 0.028 | |||||
LAYN | 0.087 | 0.095 | 0.52 | *** | |||||
Resting treg T cell | FOXP3 | − 0.002 | 0.96 | 0.15 | * | 0.42 | * | 0.6 | *** |
IL2RA | 0.19 | ** | 0.37 | * | |||||
Effector treg T cell | CTLA4 | 0.23 | *** | 0.25 | *** | 0.65 | *** | 0.68 | *** |
CCR8 | 0.21 | *** | 0.51 | ** | |||||
TNFRSF9 | 0.015 | 0.77 | 0.65 | *** |
Tumour, correlation analysis in tumour tissue of TCGA; Normal, correlation analysis in normal tissue of TCGA. *P < 0.01; **P < 0.001; ***P < 0.0001