Fig. 4.

CSF SNAP-25 concentrations using the two platforms, SNAP-25 [Simoa] (A) and MS (SNAP-25 [Long] (B) and SNAP-25 [Total] (C) in the cohort consisting of young (n = 5), cognitively unimpaired Aβ negative (CU−, n = 15), cognitively unimpaired Aβ positive (CU+, n = 10), cognitively impaired Aβ negative (CI−, n = 12), and cognitively impaired Aβ positive (CI+, n = 28). Statistical comparison was performed with Kruskal-Wallis with post hoc Dunn’s test and false discovery rate (FDR) correction for multiple comparisons using the two-stage step-up method of Benjamini, Krieger, and Yekutieli (Q = 0.05). p-values: * p ≤ 0.05 and ** p ≤ 0.01. The bars indicate median with interquartile range