TABLE 1.
Baseline characteristics for 298 172 patients with VTE and 1 185 079 matched controls, presented for all VTE as well as for DVT and PE separately
| VTE | DVT | PE | ||||
|---|---|---|---|---|---|---|
| Case | Control | Case | Control | Case | Control | |
| n = 298 172 | n = 1 185 079 | n = 156 908 | n = 623 112 | n = 141 264 | n = 561 967 | |
| Demographic factors | ||||||
| Age, y, mean (SD), median (IQR) | 68 (16.2) | 68 (16.2) | 66 (16.7) | 66 (16.7) | 69 (15.4) | 69 (15.4) |
| 71 (59‐80) | 71 (59‐80) | 70 (57‐79) | 70 (57‐79) | 73 (62‐81) | 73 (62‐81) | |
| Female sex, n (%) | 157 224 (52.7) | 625 117 (52.7) | 81 748 (52.1) | 324 678 (52.1) | 75 496 (53.4) | 300 439 (53.5) |
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |
|---|---|---|---|---|---|---|
| Comorbidities | ||||||
| Heart failure | 42 865 (14.4) | 72 228 (6.1) | 16 229 (10.3) | 35 854 (5.8) | 26 636 (18.9) | 36 374 (6.5) |
| Ischemic heart disease | 43 595 (14.6) | 106 065 (9.0) | 17 302 (11.0) | 52 964 (8.5) | 26 293 (18.6) | 53 101 (9.4) |
| Atrial fibrillation | 32 371 (10.9) | 69 977 (5.9) | 13 474 (8.6) | 34 976 (5.6) | 18 897 (13.4) | 35 001 (6.2) |
| Ischemic stroke | 21 159 (7.1) | 44 528 (3.8) | 10 302 (6.6) | 22 221 (3.6) | 10 857 (7.7) | 22 307 (4.0) |
| Hemorrhagic stroke | 4363 (1.5) | 7062 (0.6) | 2154 (1.4) | 3584 (0.6) | 2209 (1.6) | 3478 (0.6) |
| Chronic obstructive pulmonary disease | 16 588 (5.6) | 26 117 (2.2) | 6223 (4.0) | 13 148 (2.1) | 10 365 (7.3) | 12 969 (2.3) |
| Cancer | 60 397 (20.3) | 99 373 (8.4) | 30 240 (19.3) | 49 506 (7.9) | 30 157 (21.3) | 49 867 (8.9) |
| Systemic connective tissue disorders | 11 890 (4.0) | 19 371 (1.6) | 5625 (3.6) | 9577 (1.5) | 6265 (4.4) | 9794 (1.7) |
| Inflammatory bowel syndrome | 6422 (2.2) | 11 466 (1.0) | 3400 (2.2) | 6013 (1.0) | 3022 (2.1) | 5453 (1.0) |
| Liver disease | 3008 (1.0) | 4871 (0.4) | 1487 (0.9) | 2471 (0.4) | 1521 (1.1) | 2400 (0.4) |
| Kidney failure | 9751 (3.3) | 13 216 (1.1) | 4786 (3.1) | 6659 (1.1) | 4965 (3.5) | 6557 (1.2) |
| Depression | 9662 (3.2) | 18 895 (1.6) | 4510 (2.9) | 9991 (1.6) | 5152 (3.6) | 8904 (1.6) |
| Psychosis | 6819 (2.3) | 15 803 (1.3) | 3607 (2.3) | 7881 (1.3) | 3212 (2.3) | 7922 (1.4) |
| Alcohol abuse | 5701 (1.9) | 12 820 (1.1) | 3049 (1.9) | 7038 (1.1) | 2652 (1.9) | 5782 (1.0) |
| Temporary provoking factors | ||||||
| Gastrointestinal surgery | 11 930 (4.0) | 5518 (0.5) | 5027 (3.2) | 2871 (0.5) | 6903 (4.9) | 2647 (0.5) |
| Obstetric surgery | 782 (0.3) | 444 (0.0) | 432 (0.3) | 238 (0.0) | 350 (0.2) | 206 (0.0) |
| Surgery of the musculoskeletal system | 26 784 (9.0) | 8532 (0.7) | 15,111 (9.6) | 4193 (0.7) | 11 673 (8.3) | 4339 (0.8) |
| Surgery, other major | 21 442 (7.2) | 11 423 (1.0) | 10 129 (6.5) | 5846 (0.9) | 11 313 (8.0) | 5577 (1.0) |
| Trauma | 12 092 (4.1) | 4286 (0.4) | 6384 (4.1) | 2054 (0.3) | 5708 (4.0) | 2232 (0.4) |
| Lower extremity fracture | 16 051 (5.4) | 4393 (0.4) | 9043 (5.8) | 2165 (0.3) | 7008 (5.0) | 2228 (0.4) |
Comorbidities were defined as a diagnosis registered within 7 years before the VTE event and temporary provoking factors were defined as a diagnosis registered within 3 months previous to the VTE event.
DVT, deep vein thrombosis; IQR, interquartile range (Q1‐Q3); PE, pulmonary embolism; SD, standard deviation; VTE, venous thromboembolism.