TABLE 2.
Unadjusted ORs and PARs for comorbidities within 7 years of the VTE event for 156 908 patients with DVT compared to 623 112 controls and 141 264 patients with PE compared to 561 967 controls
| DVT | PE | |||
|---|---|---|---|---|
| OR case vs control (99% CI) | PAR, % | OR case vs control (99% CI) | PAR, % | |
| Comorbidities | ||||
| Heart failure | 1.98 (1.94‐2.02) | 5.1 | 3.75 (3.69‐3.82) | 13.8 |
| Ischemic heart disease | 1.35 (1.33‐1.38) | 2.9 | 2.30 (2.26‐2.34) | 10.5 |
| Atrial fibrillation | 1.62 (1.59‐1.66) | 3.3 | 2.47 (2.43‐2.52) | 8.0 |
| Ischemic stroke | 1.93 (1.89‐1.98) | 3.2 | 2.05 (2.00‐2.10) | 3.9 |
| Hemorrhagic stroke | 2.40 (2.28‐2.54) | 0.8 | 2.56 (2.42‐2.70) | 1.0 |
| Chronic obstructive pulmonary disease | 1.93 (1.87‐1.99) | 1.9 | 3.43 (3.34‐3.53) | 5.2 |
| Cancer | 2.95 (2.90‐3.00) | 12.7 | 2.97 (2.92‐3.01) | 14.1 |
| Inflammatory bowel disease | 2.29 (2.19‐2.39) | 1.2 | 2.24 (2.14‐2.35) | 1.2 |
| Depression | 1.83 (1.76‐1.90) | 1.3 | 2.38 (2.29‐2.46) | 2.1 |
| Psychosis | 1.87 (1.80‐1.95) | 1.1 | 1.66 (1.59‐1.73) | 0.9 |
| Alcohol abuse | 1.75 (1.68‐1.83) | 0.8 | 1.86 (1.78‐1.95) | 0.9 |
| Temporary provoking factor | ||||
| Gastrointestinal surgery | 7.16 (6.83‐7.50) | 2.8 | 10.82 (10.34‐11.33) | 4.4 |
| Obstetrical surgery | 7.76 (6.59‐9.14) | 0.2 | 7.48 (6.24‐8.96) | 0.2 |
| Surgery of the musculoskeletal system | 15.77 (15.22‐16.35) | 9.0 | 11.67 (11.26‐12.10) | 7.6 |
| Surgery, other major | 7.35 (7.11‐7.60) | 5.6 | 8.76 (8.47‐9.06) | 7.1 |
| Trauma | 13.36 (12.68‐14.06) | 3.8 | 11.18 (10.62‐11.77) | 3.7 |
| Lower‐extremity fracture | 17.89 (17.04‐18.78) | 5.4 | 13.46 (12.82‐14.15) | 4.6 |
CI, confidence interval; DVT, deep vein thrombosis; OR, odds ratio; PAR, population attributable risk; PE, pulmonary embolism; VTE, venous thromboembolism.