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. 2022 Jun 2;31:101291. doi: 10.1016/j.bbrep.2022.101291

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© 2022 Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Potential role of LCN2 in pancreatic cancer.

A. Biological function of LCN2 predicted via GO enrichment analysis based on the DAVID database. A1 and B1 are D37774 samples, A2 and B2 are D42113 samples, and A3 and B3 are E32051 samples. B. LCN2 core dataset based on the use of DAVID database KEGG enrichment analysis to predict the regulation pathway; C. Comparison of LCN2 expression levels corresponding to different stages of pancreatic cancer (data source: TCGA and GTEx); D. Correlation between LCN2 expression and overall survival; E. Correlation between LCN2 expression and disease free survival; F. Differential expression of LCN2 RNA level in normal tissue (n = 5) and tumor tissue (n = 5); G. Immunohistochemical staining results showing LCN2 expression in pancreatic tumor tissues; H. Immunohistochemical staining analysis of LCN2 expression (*, P < 0.05; n = 5). I. Proliferation characteristics of AsPC-1 cell lines with LCN2 expression knockdown under GEM ±conditions (*, P < 0.05).