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. 2022 Jun 3;13:227. doi: 10.1186/s13287-022-02903-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Tail-looping experiment reveals extensive expansion of FGFR3⁺ NP cells during regeneration. (a) Representative Safranin O/Fast Green staining images of each group of tail-looping models show the pathological changes after overloading and recovery. Scale bars, 100 µm. (b) Pathological scoring of NP and total IVD of each group is assessed and compared. ns = no significance, **P < 0.01, ****P < 0.0001, One-way ANOVA with post hoc Tukey test. (c) Experimental design shows that tail-looping model was generated using FGFR3;mTmG mice after Tam administration. (d, e) Representative NP (dotted circle) images from FGFR3;mTmG mice after looping and unlooping as well as the sham operation are shown. Scale bars, 100 µm. (f) The percentage of the FGFR3⁺ NP cells in total NP cells in Group Loop2w is lower than that in Group Sham2w. *P < 0.05, Unpaired Student’s t test. (g) The percentage of the FGFR3^·+ NP cells in total NP cells in Group Unloop is significantly higher than that in Group Sham4w. ****P < 0.0001, Unpaired Student’s t test