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. 2022 Feb 9;145(5):1641–1652. doi: 10.1093/brain/awac054

Table 2.

Secondary outcomes

IVIg withdrawal group IVIg continuation group Treatment comparison
n Baseline End point Mean changea n Baseline End point Mean changea Difference in mean change scores 95% CI
MRC sum score (median, range) 29 58 (38–60) 58 (41–60) 0b (−10 to −3) 31 60 (49−60) 59 (42−60) 0b (−7 to −2) 0c −1 to 0d
Grip strength (mean ± SD) 29 85.3 kPa (34.4) 73.5 kPa (31.2) −11.8 kPa (14.2) 31 79.3 kPa (29.2) 75.8 kPa (28.9) −3.5 kPa (17.8) −8.3 −16.8 to 0.2
INCAT-SS (mean ± SD) 29 5.2 (4.6) 5.6 (4.2) 0.4 (2.4) 31 3.8 (3.7) 3.5 (3.6) −0.4 (2.3) 0.8 −0.4 to 2.0
PI-NRS (mean ± SD) 28 1.6 (1.9) 2.4 (2.5) 0.8 (2.4) 29 1.8 (2.4) 2.3 (2.5) 0.5 (1.6) 0.2 −0.9 to 1.3
FSS score (mean ± SD) 27 35.0 (10.1) 35.9 (12.1) 0.9 (6.5) 29 31.9 (12.3) 32.9 (12.4) 1.0 (10.8) −0.1 −6.3 to 4.0
ALDS (mean ± SD) 27 83.2 (10.3) 80.6 (12.5) −2.6 (7.4) 30 87.4 (6.0) 86.7 (11.7) −0.7 (5.0) 1.9 −1.5 to 5.3
SF-36 (mean ± SD) 27 29
 Physical component 42.1 (9.9) 37.8 (11.2) −4.4 (9.4) 45.2 (8.5) 41.2 (10.5) −4.0 (8.9) −0.4 −5.3 to 4.5
 Mental component 50.9 (10.3) 53.1 (7.9) 2.1 (9.4) 49.7 (11.8) 47.9 (12.4) −1.8 (13.9) 3.9 −2.4 to 10.4
PGIC scale, n (%) 27 29
 Same or better than prior to study NA 10 (37%) NA NA 17 (59%) NA NA −44 to 4
 Worse than prior to the study NA 17 (63%) NA NA 12 (41%) NA NA

ALDS = AMC Linear Disability Score; FSS = Fatigue Severity Scale; INCAT-SS = INCAT Sensory Sum Score; PI-NRS = Pain Intensity Numeric Rating Scale; SF 36 = Short Form 36.

a

Reported mean changes and differences in mean changes may slightly differ from apparent differences due to rounding.

b

Median change scores on the MRC.

c

The within-group median change score was calculated as the 50th percentile of all individual differences.

d

Between-group difference on the MRC expressed in median difference in change scores; point estimate and 95% CI were analysed using the Hodges–Lehmann approach.