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. 2022 Feb 11;145(5):1624–1631. doi: 10.1093/brain/awac052

Figure 3.

Figure 3

MRI brain images from three patients with Leigh syndrome due to DNAJC30 defect. (A) MRI brain images from the first reported female childhood-onset Leigh syndrome patient (Patient 1) taken at 7 years of age demonstrating bilateral signal intensity changes in the putamina and the pedunculi cerebelli (arrows).(B) MRI brain images from the second reported female childhood-onset Leigh syndrome patient (Patient 2) taken at 12 years of age demonstrating bilateral signal intensity changes in the putamina and the heads of caudate nuclei (arrows). The volume of the putamina and caudate heads is decreased bilaterally. (C) MRI brain images from the male adult-onset DNAJC30-associated Leigh syndrome patient (Patient 3) taken at 24 years of age demonstrating bilateral signal intensity changes in the posterior basal ganglia (arrows).