Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 24;145(5):1598–1609. doi: 10.1093/brain/awac077

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

An overview of current biomarker development in frontotemporal dementia and amyotrophic lateral sclerosis. The main genetic biomarkers evaluated are TDP-43, MAPT, C9ORF72 and SOD1. Neurofilament biomarkers evaluated are NfL and NfH. The main immune-related biomarkers evaluated are YKL-40, GFAP and CST3. All of these markers have limitations in the diagnosis of frontotemporal dementia and amyotrophic lateral sclerosis, and therefore there is an urgent need for new biomarker development for the two diseases.