Figure 3.

¹⁸F-MK-6240 tau-PET scans in symptomatic non-tau mutation subjects. A higher SUVR represents stronger binding. Binding to meninges, including the tentorium cerebelli, is considered to be off-target. Scans are masked to minimize off-target binding to meninges. (A) A 51-year-old male with bvFTD/svPPA due to VCP mutation, FTLD-CDR 0.5, MMSE 23/25. (B) A 41-year-old male with bvFTD due to C9orf72 mutation, FTLD-CDR 0.5, MMSE 27/30. (C) A 44-year-old male with bvFTD due to C9orf72 mutation, FTLD-CDR 2, MMSE 12/30. (D) A 61-year-old male with bvFTD due to GRN mutation, FTLD-CDR 1, MMSE 19/30.