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. 2021 Nov 23;145(5):1668–1683. doi: 10.1093/brain/awab327

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Seizure patterns in a subset of individuals with STXBP1-related disorders. (A) Cumulative distribution of seizure onset in 427 individuals and seizure offset in 80 individuals, highlighting 89% of individuals with seizure onset in the first year of life and offset within the first 5 years. Seizure onset interquartile range (IQR): 0.24–5.0 months. Seizure offset IQR: 5.75 months–1.6 years. (B) Changes in seizure frequency in monthly intervals during the first year of life, indicating a dynamic course of seizures in individuals with STXBP1. Progression in blue between monthly increments indicates seizure improvement, whereas yellow indicates seizures worsening and grey indicates no change in seizure frequency.