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. 2021 Nov 23;145(5):1668–1683. doi: 10.1093/brain/awab327

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© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparative effectiveness assessment of ASM and treatment responses. (A) Selection of ASM prescriptions extracted from the EMR, across ages 0–5 years in a subset of individuals with STXBP1. (B) Extension of A, showing the distribution of individuals on ASM and ketogenic diet across ages 0–20 years. (C) Relative effectiveness of ASM in reducing seizure frequency. (D) Relative effectiveness of ASM in reducing seizure frequency or maintaining seizure freedom. (E) Relative effectiveness of ASM in maintaining seizure freedom. Odds ratios were calculated based on changes in seizure frequency to ASM use across monthly time intervals.