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. 2022 Jun 3;13:226. doi: 10.1186/s13287-022-02895-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 16 — Proposed mechanism of UC-MSC-mediated alleviation of muscle mass loss and dysfunction in a SAMP10 mouse model. UC-MSCs: umbilical cord-derived mesenchymal stromal cells, AMPK: adenosine monophosphate (AMP)-activated protein kinase, mTOR: mammalian target rapamycin, HGF: hepatocyte growth factor, VEGF: vascular endothelial cell growth factor, PGC-1α: peroxisome proliferator-activator-γ coactivator-1α, MCP-1: monocyte chemoattractant protein-1, COX-IV, cytochrome c oxidase subunit 4; GLUT-4, glucose transporter-4; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling; CatK, cathepsin K; PCNA, proliferating cell nuclear antigen; TNF-α: tumor necrosis factor-alpha, TLR-2, toll-like receptor-2