Table 3.
Association of unweighted PRS in different subgroups of endometriosis patients
| Crude OR (95% CI) | p-value | Adj. OR (95% CI) |
p-value | |||
|---|---|---|---|---|---|---|
| Isolated/spread | Isolated/spread | p-value | ||||
| Quartile 1 | 8/19 | 0.027 | 1.000 | 1.000 | ||
| Quartile 2 | 17/23 |
0.570 0.202–1.607 |
0.288 |
0.459 (0.137–1.537) |
0.206 | |
| Quartile 3 | 23/16 |
0.293 (0.103–0.832) |
0.021 |
0.182 (0.052–0.630) |
0.007 | |
| Quartile 4 | 8/22 |
1.158 0.364–3.680) |
0.804 |
0.741 (0.197–2.781) |
0.657 | |
| P for trend | 0.349 | |||||
| No GI tract involvement /GI tract involvement | No GI tract not involvement /GI tract involvement | p-value | ||||
| Quartile 1 | 21/6 | 0.029 | 1.000 | 1.000 | ||
| Quartile 2 | 35/5 |
0.500 (0.136–1.843) |
0.298 |
0.196 (0.037–1.044) |
0.056 | |
| Quartile 3 | 33/6 |
0.656 (0.186–2.310) |
0.512 |
0.413 (0.090–1.897) |
0.256 | |
| Quartile 4 | 18/18 |
2.333 (0.728–7.479) |
0.154 |
2.354 (0.557–9.950) |
0.244 | |
| P for trend | 0.065 | |||||
|
No GI symptoms/ GI symptoms |
No GI-symptoms/ GI-symptoms |
p-value | ||||
| Quartile 1 | 5/24 | 0.238 | 1.000 | 1.000 | ||
| Quartile 2 | 3/36 |
2.500 (0.546–11.450) |
0.238 |
5.515 (0.666–45.659) |
0.113 | |
| Quartile 3 | 6/33 |
1.146 (0.313–4.196) |
0.837 |
1.265 (0.238–6.722) |
0.782 | |
| Quartile 4 | 8/23 |
0.599 (0.171–2.101) |
0.424 |
0.410 (0.075–2.236) |
0.303 | |
| P for trend | 0.146 | |||||
| No hormone therapy /hormone therapy | No hormone therapy /hormone therapy | p-value | ||||
| Quartile 1 | 13/16 | 0.484 | 1.000 | 1.000 | ||
| Quartile 2 | 22/19 |
0.702 (0.270–1.824) |
0.467 |
0.507 (0.161–1.600) |
0.247 | |
| Quartile 3 | 25/14 |
0.455 (0.170–1.214) |
0.116 |
0.250 (0.075–0.829) |
0.023 | |
| Quartile 4 | 17/14 |
0.669 (0.242–1.852) |
0.439 |
0.473 (0.139–1.604) |
0.229 | |
| P for trend | 0.128 |
Adj = adjusted, CI = confidence, OR = odds ratio. PRS = polygenic risk scores. ORs and 95% CI were calculated using binary logistic regression model, adjusted for PC1, PC2, PC3 and PC4. The calculations with isolated/spread endometriosis, no GI-symptoms/GI-symptoms and no hormone/hormone therapy were also adjusted for age. The calculations with no GI-symptoms/GI-symptoms was also adjusted for hormone therapy. Fisher´s exact test was used to calculate the distribution of PRS quartiles among groups. P-values < 0.05 were considered statistically significant