TABLE 2.
Design of in vivo trialsa
| Period and process | Strains given to volunteers:
|
||
|---|---|---|---|
| 1, 4, 7, 10 | 2, 5, 8, 11 | 3, 6, 9, 12 | |
| I | |||
| Interventionb | C | A | B |
| Washoutc | |||
| II | |||
| Intervention | A | B | C |
| Washout | |||
| III | |||
| Intervention | B | C | A |
| Washout | |||
a
Fecal samples were taken at days 5, 18, 23, and 29 in each period. Strains were administered to 12 healthy male volunteers as follows: A, DSM 12246 and 19070-2; B, LGG, CHCC 3137, and CHCC 2329; C, placebo. For descriptions of strains, see Table 1.
b
Days 1 to 18.
c
Days 19 to 35.