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. 2022 Jun 3;8(22):eabn3815. doi: 10.1126/sciadv.abn3815

Fig. 1. Mapping of oxidized guanines by CD-seq.

Fig. 1.

(A) Outline of the CD-seq method. (B) Outline of the enzymatic cleavage procedure to map 8-oxo-dG at single-base resolution. (C) Genome browser view of divergent DNA sequencing read pairs on chromosome 11 at the MICAL2 gene. Orange and lavender segments represent the divergent read pairs. Red arrows indicate single-base gaps matching the excised DNA base. (D) Genome browser view of divergent DNA sequencing read pairs on chromosome 17 at the EVPL gene. ds, double strand; DSB, double-strand break.