Fig. 3. Sequence context of 8-oxo-dG formation in human fibroblasts treated with H₂O₂.

(A) Trinucleotide sequence context of read gaps in control cells (no treatment). (B to D) Trinucleotide sequence context of read gaps in cells treated with 5 mM (B) or 10 mM (C and D) H₂O₂. The read depth was 90 million reads in (C) or 540 million reads in (D). (E) Sequence context of guanine oxidation by using logo plot analysis. Position 11 represents the base in the divergent read gaps. At each base position, the height of each letter represents the relative frequency of that nucleic acid base.