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. 2022 Jun 3;8(22):eabn3815. doi: 10.1126/sciadv.abn3815

Fig. 4. 8-Oxo-dG signature and cancer mutational signatures.

Fig. 4.

(A) COSMIC signatures SBS18 and SBS36 in comparison to the 8-oxo-dG signature. For the cancer signatures, only the C>A and T>A mutation windows are shown. The 8-oxo-dG DNA damage signature is displayed to reflect the style of cancer mutation signatures. (B) Heatmap showing the cosine similarity scores for 8-oxo-dG mapping at the trinucleotide level and the COSMIC mutational signatures found in the COSMIC v3.2 mutation database. We used the sum of all C to N and T to N mutation windows for comparisons with the 8-oxo-dG trinucleotide signature. We excluded COSMIC signatures that are thought to be sequencing artifacts. Darker green colors indicate higher similarity. Signatures SBS18 and SBS36 are indicated by dotted round rectangles.