Table 4.
Pharmacokinetic parameters of GS-441524 in the rat maternal blood, placenta, fetus, and amniotic fluid, after remdesivir (30 mg/kg, i.v.) administration.
| Parameters | remdesivir (30 mg/kg, i.v.) |
|||
|---|---|---|---|---|
| blood | placenta | fetus | amniotic fluid | |
| Non-compartment model | ||||
| AUClast (min μg/mL) | 23.40 ± 2.46 | 8.39 ± 2.13* | 10.85 ± 3.46 | 16.70 ± 4.48 |
| Cmax (ng/mL) | 135.97 ± 16.11 | 49.02 ± 12.22* | 62.43 ± 18.03* | 92.39 ± 21.97 |
| Tmax (min) | 87 ± 11 | 143 ± 14 | 136 ± 23 | 143 ± 20 |
| t1/2 (min) | 192 ± 14 | 182 ± 31 | 123 ± 22 | 201 ± 27 |
| AUCtissue/AUCblood | - | 0.35 ± 0.09 | 0.46 ± 0.14 | 0.71 ± 0.19 |
AUCtissue/AUCblood represents the maternal blood-to-tissue transfer ratio.
Data have been expressed as mean ± SEM (n=6).
⁎
p<0.05, compared with maternal blood within groups, as assessed using ANOVA with Tukey's HSD post-hoc test.