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. 2022 May 5;41(23):3263–3277. doi: 10.1038/s41388-022-02333-7

Fig. 6. Pathway analysis of androgen and AA-modulated angiogenic factors.

Fig. 6

a GSEA plot of sprouting angiogenesis gene set using RNA normalised counts indicates positive enrichment of the gene set by R1881 compared to DMSO; FDR q-value= 0.062 and counteraction by AA, FDR q value = 0.103. b Regulation of mRNAs by AR ligands for specific angiogenic factors derived from RNA-seq data of androgen- and AA-treated C4-2 cells for 72 h (n = 3). qRT-PCR of extracted RNA from C4-2 xenograft tumours indicated expression changes of pro-angiogenic (c) and anti-angiogenic factors (d). Mice were treated under the same condition as described in Fig. 4a (n = 5, two-tailed student’s t test).