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. 2022 May 5;41(23):3263–3277. doi: 10.1038/s41388-022-02333-7

Fig. 7. ANGPT2 expression is associated with PCa Gleason score and is inhibited by AA in PCa patients treated ex vivo.

Fig. 7

a Analyses of TCGA database distinguishing the two ANGPT2 transcript variants. X-axis represents Gleason scores of patient tissues (bold numbers). The number in parenthesis indicates the number of patient samples. Mann–Whitney–Wilcoxon test on log transformed FPKM, two tailed, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. b Comparison of ANGPT2 mRNA expression between the human castration-sensitive LNCaP and castration-resistant C4-2 cells. Cells were treated with 1 nM R1881 or DMSO as control. TBP served as housekeeping gene. n = 3; two-tailed student’s t test. c qRT-PCR analyses of ANGPT2 levels of extracted RNA from native patient PCa samples treated ex vivo with 100 μM AA for 48 h.