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. 2022 Jun 3;13:3100. doi: 10.1038/s41467-022-30864-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The number of participants for each group (placebo group, pink; 3 μg group, green; 6 μg group, blue) at each visit included in the analysis is provided below the bars. Dots are reciprocal neutralising antibody titres for individuals in the per-protocol population. Numbers above the bars are geometric mean titres (GMTs), and error bars indicate 95% CIs. GMTs and corresponding 95% CIs were calculated on the basis of standard normal distributions of log-transformed antibody titres. Numbers above the short horizontal lines are p values for comparisons between 3 μg group and 6 μg group using group t tests with log-transformation (two-sided). Titres lower than the limit of detection (1:4) are presented as half the limit of detection. The dotted horizontal line represents the protective threshold (1:33).