Table 1.
Demographic variables and imaging parameters of patients and controls.
| Total | CSVD | controls | Age matched CSVD | P1* | P2* | |
|---|---|---|---|---|---|---|
| Gender (m/f) | 15/21 | 12/15 | 3/6 | 4/5 | 0.641 | 0.730 |
| MRI (1.5 T/3 T) | 22/14 | 17/10 | 5/4 | 6/3 | 0.747 | 0.730 |
| Fazekas (score 0/1/2/3) | 9/14/10/3 | 0/14/10/3 | 9/0/0/0 | 0/5/4/0 | ||
| Fazekas (median; IQR) | 1; 2 | 1; 1 | 0;0 | 1; 1 | < 0.001 | < 0.001 |
| Age (years) | 63 ± 10 | 65 ± 11 | 57 ± 5 | 57 ± 4 | 0.073 | 1.000 |
| MoCA | 25 ± 4 | 25 ± 4 | 25 ± 3 | 26 ± 3 | 0.971 | 0.436 |
| Cognitively impaired49 | 19% | 22% | 11% | 11% | ||
| WMRI | 0.408 ± 0.663 | 0.536 ± 0.724 | 0.025 ± 0.027 | 0.232 ± 0.292 | < 0.001 | 0.006 |
| NOL | 14 ± 9 | 17 ± 9 | 6 ± 6 | 13 ± 9 | < 0.001 | 0.031 |
| Total retina volume (mm3) | 2.32 ± 0.01 | 2.31 ± 0.11 | 2.36 ± 0.07 | 2.31 ± 0.08 | 0.101 | 0.136 |
Values are mean ± SD and the volume of the retina corresponds to the foveal and parafoveal volumes (3-mm-circle). *Mann–Whitney-U-test was performed to compare the groups. P1, comparison between all patients and controls; P2, comparison between age matched patients and control. Significant results (p < 0.05) are displayed in bold.
CSVD, patients with cerebral small vessel disease; MRI, device used for MRI imaging; 1.5 T, Philips Ingenia 1.5 T; 3 T, Achieva TX 3 T, m, male; f, female; Fazekas, Fazekas score; IQR, interquartile range; MoCA, Montreal Cognitive Assessment; WMRI, white matter lesions volume ratio index; NOL, number of white matter lesions.