Table 2.
Comparison of structural retinal parameters between patients with cerebral small vessel disease and age-matched controls.
| Parameter | Controls | CSVD | P* |
|---|---|---|---|
| GCL (mm3) | 0.34 ± 0.02 | 0.30 ± 0.02 | 0.008 |
| Foveal | 0.01 ± 0.00 | 0.01 ± 0.00 | 0.730 |
| Pf. nasal | 0.08 ± 0.01 | 0.07 ± 0.00 | 0.014 |
| Pf. inferior | 0.08 ± 0.01 | 0.07 ± 0.01 | 0.019 |
| Pf. temporal | 0.08 ± 0.00 | 0.07 ± 0.01 | 0.063 |
| Pf. superior | 0.08 ± 0.00 | 0.07 ± 0.01 | 0.011 |
| IPL (mm3) | 0.28 ± 0.02 | 0.27 ± 0.02 | 0.094 |
| INL (mm3) | 0.27 ± 0.02 | 0.27 ± 0.02 | 1.00 |
| OPL (mm3) | 0.22 ± 0.06 | 0.20 ± 0.02 | 0.340 |
| ONL (mm3) | 0.51 ± 0.06 | 0.55 ± 0.03 | 0.094 |
| RPE (mm3) | 0.11 ± 0.02 | 0.10 ± 0.02 | 0.387 |
| pRNFL (µm) | 75 ± 6 | 72 ± 4 | 0.222 |
| MRW (µm) | 341 ± 66 | 333 ± 65 | 0.796 |
Values are mean ± SD and the volumes of the macular layers correspond to the foveal and parafoveal volumes (3-mm-circle). *Mann–Whitney-U-test was performed to compare the two groups. Significant results (p < 0.05) are displayed in bold.
CSVD, patients with cerebral small vessel disease; GCL, ganglion cell layer; pf., parafoveal; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; RPE, retinal pigment epithelium; pRNFL, peripapillary retinal nerve fiber layer; MRW, Bruch’s membrane opening-minimum rim width.