Table 4.
Results of linear regression of structural retinal parameters and number of white matter lesions in patients with cerebral small vessel disease.
| Structural retinal parameter | NOL association | NOL association, age adjusted | ||
|---|---|---|---|---|
| β [95%-CI] | p | β [95%-CI] | p | |
| Total retina | ||||
| Pf. superior | − 159.270 [− 316.458, − 2.082] | 0.047 | − 99.825 [− 243.197, 43.547] | 0.164 |
| GCL | ||||
| Total volume | − 72.052 [− 159.997, 15.894] | 0.104 | − 72.245 [− 144.055, − 0.435] | 0.049 |
| Foveal | − 591.667 [− 1671.649, 488.315] | 0.270 | − 874.843 [− 1743.724, − 5.961] | 0.049 |
| Pf. nasal | − 269.435 [− 635.884, 97.014] | 0.142 | − 306.899 [− 602.325, − 11.473] | 0.042 |
| IPL | ||||
| Pf. nasal | − 693.590 [− 1237.220, − 149.959] | 0.014 | − 500.646 [− 993.331, − 7.961] | 0.047 |
| Pf. inferior | − 452.976 [− 827.535, − 78.417] | 0.020 | − 336.222 [− 668.912, − 3.533] | 0.048 |
| OPL | ||||
| Foveal | 1550.000 [442.428, 2657.572] | 0.008 | 1129.675 [112.316, 2147.033] | 0.031 |
| Pf. superior | 412.534[110.271, 714.797] | 0.009 | 268.754 [− 25.311, 562.819] | 0.071 |
| ONL | ||||
| Pf. superior | − 325.122 [− 557.611, − 92.634] | 0.008 | − 173.958 [− 433.211, 85.294] | 0.179 |
| pRNFL | ||||
| N/T | 15.701 [− 2.940, 34.341] | 0.095 | 15.711 [0.737, 30.685] | 0.041 |
| Temporal | − 0.475 [− 0.853, − 0.097] | 0.016 | − 0.432 [− 0.736, − 0.128] | 0.007 |
| PMB | − 0.481 [− 0.993, 0.030] | 0.064 | − 0.487 [− 0.893, − 0.081] | 0.021 |
| Temporal superior | − 0.226 [− 0.443, − 0.008] | 0.043 | − 0.189 [− 0.371, − 0.008] | 0.041 |
| MRW | ||||
| Total | − 0.074 [− 0.128, − 0.020] | 0.009 | − 0.055 [− 0.103, − 0.007] | 0.027 |
| Nasal | − 0.068 [− 0.110, − 0.026] | 0.003 | − 0.050 [− 0.089, − 0.010] | 0.016 |
| Nasal inferior | − 0.067 [− 0.108, − 0.026] | 0.002 | − 0.059 [− 0.092, − 0.026] | 0.001 |
| Temporal inferior | − 0.076 [− 0.120, − 0.031] | 0.002 | − 0.065 [− 0.101, − 0.028] | 0.001 |
| Temporal | − 0.067 [− 0.116, − 0.019] | 0.009 | − 0.048 [− 0.092, − 0.003] | 0.039 |
| PMB | − 0.063 [− 0.107, − 0.018] | 0.008 | − 0.042 [− 0.085, 0.000] | 0.050 |
| Temporal superior | − 0.054 [− 0.105, − 0.004] | 0.035 | − 0.039 [− 0.083, 0.006] | 0.085 |
| Nasal superior | − 0.065 [− 0.109, − 0.020] | 0.006 | − 0.046 [− 0.087, − 0.005] | 0.029 |
Associations between retinal parameters and NOL were assessed using linear regression. Model 1: univariate regression, Model 2: multivariable regression adjusted for age; significant associations (p < 0.05) are displayed in bold.
In this table, only parameters are listed with a p value < 0.05 in at least one linear regression model. Further results are listed in the supplement. The volumes of the macular layers correspond to the foveal and parafoveal volumes (3-mm-circle).
NOL, number of white matter lesions; β, standardized coefficient; CI, confidence interval; pf., parafoveal; GCL, ganglion cell layer; IPL, inner plexiform layer; OPL, outer plexiform layer; ONL, outer nuclear layer; pRNFL, peripapillary retinal nerve fiber layer; N/T, ratio nasal to temporal; PMB, papillo-macular bundle; MRW, Bruch’s membrane opening-minimum rim width.