Fig. 5. Human-microbial-lectin prevalence and diversity.

a All domains present in the human-microbial lectin dataset are organized based on co-occurrence between a carbohydrate-binding domain and secondary domains in the same lectin. Bar graphs summarize the count of each domain in the dataset and box color reflects the frequency of domain co-occurrence. b Lectin domain architectures containing the Cbeg4/5 carbohydrate-binding domain (IPR33803) and the Bacteroidetes-Associated Carbohydrate-binding Often N-terminal domain (IPR024361) are pictured. IPR0244361 is the most common domain in the human-microbial-lectin dataset and present in 891 lectins. The most prevalent lectins (top 10% for each body site) containing these domains are pictured. For IPR33803 only the Cbeg4/5 domain architecture is identified in abundance in patient samples. c prevalence of human-microbial-lectins in patient samples from the Human Microbiome Project. Red bar is mean ± SEM. Summary of the average number of human-microbial-lectins per person for each body site is pictured. Color of circle is proportional to the mean lectin count with stool set as 100%. d Overlap of lectin genes between five body sites. e Rarefaction analysis of human-microbial-lectin genes for each body site based on number of samples from the Human Microbiome Project. Stool is pictured on a separate plot due to the large number of lectin sequences. Human digestive tract image in c is from the National Institute of Diabetes and Digestive and Kidney Diseases media library.