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. 2022 Jun 3;13:3111. doi: 10.1038/s41467-022-30575-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Representative sequence showing CTL (OT1) positions on the spheroid, caspase 3/7 fluorescent death marker, and B16 cell fragmentation. The white arrow at 3h indicates the appearance of capsase signal next to a CTL. At 9 h it represents a fragmented dead cell. b Representative chronology showing the key events for a given spheroid interaction with CTLs: Contact times of CTLs on spheroids, detection of caspase 3/7 signal, detection of fragmentation events. c Time of first caspase signal vs. first observation of cell fragmentation. d Percentage of WT (black) and OVA (red) spheroids that show at least one fragmentation event in under 14 h. N equals 54 and 84 spheroids, respectively. The error bar is the SEM. Source data are provided as a Source data file.