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. 2022 Jun 3;13(6):523. doi: 10.1038/s41419-022-04980-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — MNNG/HOS cells treated with or without SGLT2 inhibitor (canagliflozin, 1 uM) for 24 h were harvested for RNA sequencing analysis, and Volcano plot (a) and heatmap (b) showed the differentially expressed genes in MNNG/HOS cells treated with or without SGLT2 inhibitor. Green points represent downregulated genes, while red points represent upregulated genes. c Histogram of the GO-enriched pathways related with immune infiltration in the SGLT2 inhibitor treatment group. d TIMER web tool was used to search the relationship of the mRNA expression level of SGLT2 and the infiltration level of CD8⁺ T cells, CD4⁺ T cells, and CD4⁺ Th2 cells in osteosarcoma. e K7M2 tumor growth curves (n = 5/group) of different groups (***p < 0.001). NS normal saline. f, g Immunofluorescence staining analysis of the percentage of CD3⁺CD4⁺ and CD3⁺CD8⁺ T cells infiltrated in K7M2 tumors (f). Data are presented as the mean ± SD (g, n = 5/group, ***p < 0.001).