Table 1.
Organ involvement and presenting symptoms at diagnosis in unifocal adult Langerhans cell histiocytosis.
| Systems involved | # of cases (n = 44) |
Specific sites | Presenting symptoms |
|---|---|---|---|
| Bone | 19 (43%) | Cranium (11) | Skull pain/swelling (9) |
| Vertebrae (3) | Back pain (3) | ||
| Mandible (1) | Joint pain (2) | ||
| Orbit (1) | Decreased hearing (2) | ||
| Femur (1) | Rib pain (1) | ||
| Rib (1) | Eye swelling (1) | ||
| Pelvis (1) | Periodontal disease (1) | ||
| Skin | 11 (25%) | Face (2) | Skin lesion NOS (4) |
| Upper extremity (2) | Non-pruritic papule (1) | ||
| Lower extremity (2) | Erythematous papules (1) | ||
| Vulva (2) | Pedunculated papule (1) | ||
| Chest (1) | Acneiform papule (1) | ||
| Flank (1) | Hyperpigmented linear papule (1) | ||
| Scalp (1) | Non-healing papule with central ulceration (1) | ||
| Pruritic lesion NOS (1) | |||
| Hypothalamic-pituitary axis | 6 (14%) | Hypothalamus (3) | Polyuria/polydipsia (4) |
| Pituitary (2) | Headache (2) | ||
| Infundibulum (1) | Weight gain (2) | ||
| Menstrual changes (1) | |||
| Cognitive changes (1) | |||
| Gastrointestinal | 5 (12%) | Colon (3) | Abdominal pain (2) |
| Rectum (1) | Diarrhea (2) | ||
| Stomach (1) | Melena (1) | ||
| Asymptomatic (1) | |||
| Lymph node | 1 (2%) | Inguinal (1) | Groin swelling (1) |
| Reproductive | 1 (2%) | Cervix (1) | Cervical nodule (1) |
| Mucosa | 1 (2%) | Conjunctiva (1) | Eye itching (1) |