. 2022 Jun 3;12:228. doi: 10.1038/s41398-022-01987-x

Table 2.

Changes in CARS and cytokine levels after the treatment in three immuno-behavioural groups.

	Best responding group (n = 17)				Least responding group (n = 18)				Medium responding group (n = 44)				$χ_{2}^{2}$	p^d
	mean(SD)	t^a	Hedge’s g	p^d	mean(SD)	t^b	Hedge’s g	p^d	mean (SD)	t^c	Hedge’s g	p^d	$χ_{2}^{2}$	p^d
CARS_total	3.32 (1.47)	9.34	2.16	<0.001	1.03 (0.96)	4.53	1.02	<0.001	1.41 (0.97)	9.61	1.42	<0.001	25.69	<0.001
CARS_S	2.15 (1.13)	7.84	1.81	<0.001	0.64 (0.87)	3.11	0.70	0.010	0.86 (0.76)	7.56	1.14	<0.001	20.35	<0.001
CARS_N	0.35 (0.58)	2.51	0.58	0.026	0.69 (0.55)	5.40	1.21	<0.001	0.20 (0.52)	2.61	0.39	0.016	10.63	0.005
CARS_D	0.91 (0.51)	7.41	1.71	<0.001	−0.06 (0.42)	−0.57	−0.13	0.579	0.39 (0.34)	7.57	1.14	<0.001	30.33	<0.001
IFN-γ	−0.37 (14.72)	−0.10	−0.02	0.927	−14.50 (10.46)	−5.88	−1.32	<0.001	−3.83 (9.54)	−2.66	−0.39	0.016	13.81	0.002
IFN-α2	11.15 (12.60)	3.65	0.84	0.006	−1.63 (7.87)	−0.88	−0.20	0.502	4.68 (10.00)	3.10	0.46	0.008	12.46	0.002
MIG	586.62 (777.11)	3.11	0.72	0.012	−698.83 (623.10)	−4.76	−1.07	<0.001	−6.53 (470.77)	−0.09	−0.01	0.927	31.68	<0.001

CARS_total CARS total score, CARS_S CARS score on social impairment domain, CARS_N CARS score on negative emotionality domain, CARS_D CARS score on distorted sensory response domain, IFN-γ Interferon gamma, IFN-α2 interferon alpha 2, MIG monokine induced by gamma interferon.

^aThe degree of freedom for the One-sample t-test statistic is 16.

^bThe degree of freedom for the One-sample t-test statistic is 17.

^cThe degree of freedom for the One-sample t-test statistic is 43.

^dFDR correction for multiple comparisons.