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. 2022 May 17;54(5):639–652. doi: 10.1038/s12276-022-00770-8

Fig. 4. Systemic delivery of PP-007 induces HO-1 expression in lung macrophages.

Fig. 4

a qPCR of Hmox-1 in white blood cells and lung tissues and densitometric analysis of HO-1 protein levels in lung tissues from WT and CF mice at different time points after PP-007 treatment. Time 0 indicates values for vehicle-treated WT and CF mice. Data are shown as the fold increase in PP-007-treated mice relative to vehicle-treated mice. The graphs show the mean ± SEM and are a combination of two independent experiments with 2–5 mice/time point for each genotype. b Representative immunofluorescence (IF) staining for CD68 (green), HO-1 (red), and DAPI (blue) in lung tissues from WT mice 24 h after PP-007 treatment. Merged images and the magnifications of areas of interest are shown on the right. Yellow staining indicates CD68 and HO-1 colocalization.