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. 2022 Mar 5;42(4):771–782. doi: 10.1007/s10875-022-01233-5

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Fig. 4 — Defective targeting of somatic hypermutation in AID-ΔE4a patients. a Mutational frequency in the variable region of the immunoglobulin heavy chain of sorted non-switched memory B cells (CD19⁺CD27⁺IgM⁺) from AD-AID and AID-ΔE4a patients; each symbol represents one sequence, horizontal lines indicate the mean; p-value as computed by two-tailed, unpaired Student’s t-test. b Mean mutational frequency of framework and complementarity-determining regions (FR and CDR, respectively) within indicated group of patients and healthy controls (HC). (Statistical significances as determined by Chi-square test with Yates’ correction are indicated, ****, p < 0.0001). c Ratios of replacement (R) versus silent mutations (S) in framework and complementarity determining-regions. (Statistical significances as determined by Fisher’s exact t test; ***, p < 0.001; ****, p < 0.0001). d Frequency of mutations located in indicated hotspot motives out of all mutations in healthy controls (HC), AD-AID and AID-ΔE4a patients (on the left: mutations in either WRCY/RGYW or WA/TW). (Statistical significances as determined by Fisher’s exact t test between the two indicated groups; ***, p < 0.001; ns, not significant)