TABLE 1.
Relatedness of the C. beijerinckii ALDH and selected members of the extended ALDH family
| Organism and proteina | Conserved region
|
% Identity based on the full length of C. beijerinckii NRRL B593 ALDH | Accession no. | ||
|---|---|---|---|---|---|
| Positionsb | E valuec | % Identityd | |||
| Giant octopus Ω-crystallin | 2–423, 8–449 | 0.047 | 18.7 (86/460) | 18.4 | L06902 |
| S. typhimurium EutE | 35–466, 31–460 | 1 × 10−101 | 44.3 (192/433) | 41.0 | AAA80209 |
| Entamoeba histolytica Adh2 | 36–431, 9–415 | 1 × 10−45 | 29.8 (122/410) | 26.1 | Q24803 |
| G. intestinalis AdhE | 36–454, 22–448 | 4 × 10−36 | 28.3 (123/435) | 26.3 | U93353 |
| C. kluyveri SSDH | 39–417, 6–382 | 5 × 10−42 | 29.5 (114/387) | 24.4 | P38947 |
| C. acetobutylicum Aad/AdhE | 50–439, 19–409 | 3 × 10−41 | 29.9 (120/402) | 25.6 | P33744 |
| E. coli AdhE | 58–433, 26–406 | 4 × 10−48 | 31.4 (122/389) | 26.1 | P17547 |
| L. lactis AdhE | 58–433, 47–431 | 9 × 10−39 | 28.8 (111/386) | 23.7 | CAA04467 |
| Rat class 3 ALDH | 128–466, 99–429 | 6 × 10−7 | 19.5 (69/354) | 14.7 | P11883 |
a
Abbreviations: Aad, AdhE, and Adh2, aldehyde-alcohol dehydrogenases; EutE, acetaldehyde dehydrogenase encoded by the eutE gene; SSDH, succinate-semialdehyde dehydrogenase.
b
The first range in each pair corresponds to the C. beijerinckii NRRL B593 ALDH; the second corresponds to the protein listed in the left column on that line.
c
The E value is the number of times one expects to see such a match (or a better one) merely by chance.
d
The percent identity is based on the total number of positions used in the alignment, including the introduced gaps.