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. 2022 May 27;2022:8267891. doi: 10.1155/2022/8267891

Figure 2.

Figure 2

Overexpression of miR-205-5p inhibited cell proliferation and induced cell apoptosis and cell cycle arrest in GC. NC mimic and miR-205-5p mimic were transfected into AGS and SGC-7901 cells by using Lipofectamine 2000. (a) Cell viability of transfected AGS and SGC-7901 cells detected by using the CCK-8 assay. (b) Colony formation on transfected AGS and SGC-7901 cells. (c) Cell apoptosis and (d) cell cycle of transfected AGS and SGC-7901 cells detected by flow cytometry. (e) The protein expression of cyclin D1, CDK2, and P21 detected in transfected AGS and SGC-7901 cells by western blot. ∗p <0.05, ∗∗p <0.01 and ∗∗∗p <0.001 vs. NC mimic. All experiments were performed in triplicate and repeated at least three times.