Table 2.
Univariate and multivariate analyses of 3-year recurrence-free survival
| Variables | % 3-year RFS (95% CI) | Univariate | Multivariate | ||
|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | ||
| Age | |||||
| < 60 | 78.01 (74.16, 82.06) | 1.0 (reference) | |||
| ≥ 60 | 77.13 (73.00, 81.50) | 1.03 (0.72, 1.09) | 0.27 | ||
| BMI | |||||
| < 24 | 76.54 (73.02, 80.20) | 1.0 (reference) | |||
| ≥ 24 | 79.79 (75.07, 84.80) | 0.99 (0.79, 1.23) | 0.93 | ||
| Sex | |||||
| Male | 77.95 (74.26, 81.82) | 1.0 (reference) | |||
| Female | 77.10 (72.74, 81.73) | 1.13 (0.91, 1.39) | 0.24 | ||
| Tumor location | |||||
| Right colon | 78.01 (74.16, 82.06) | 1.0 (reference) | |||
| Left colon | 77.13 (73.00, 81.50) | 0.97 (0.72, 1.31) | 0.86 | ||
| Rectum | 75.13 (71.29, 79.91) | 0.99 (0.76, 1.29) | 0.54 | ||
| Surgical approach | |||||
| OR | 76.31 (72.54, 80.28) | 1.0 (reference) | |||
| LR | 79.39 (75.17, 83.85) | 0.93 (0.78, 1.16) | 0.52 | ||
| Tumor differentiation | |||||
| Well | 85.71 (77.02, 95.39) | 1.0 (reference) | |||
| Moderate | 79.05 (75.53, 82.73) | 1.23 (0.72, 2.10) | 0.43 | ||
| Poor-undifferentiated | 69.91 (63.77, 76.65) | 2.15 (0.98, 3.21) | 0.07 | ||
| Mucinous type | |||||
| No | 77.52 (74.63, 80.53) | 1.0 (reference) | |||
| Yes | 79.62 (66.30, 95.61) | 0.81 (0.53, 1.26) | 0.76 | ||
| Pathology T stage | |||||
| T1 | 92.35 (86.13, 99.03) | 1.0 (reference) | |||
| T2 | 90.14 (85.66, 94.84) | 1.61 (0.21, 12.35) | 0.64 | ||
| T3 | 73.04 (69.42, 76.85) | 5.48 (0.77, 39.07) | 0.08 | ||
| T4 | 53.03 (35.38, 79.49) | 5.24 (0.69, 39.42) | 0.10 | ||
| Lymph node yield | |||||
| ≥ 12 | 92.35 (86.13, 99.03) | 1.0 (reference) | |||
| < 12 | 90.14 (85.66, 94.84) | 0.93 (0.72, 1.21) | 0.62 | ||
| Adjuvant chemotherapy | |||||
| Yes | 62.67 (51.41, 76.41) | 1.0 (reference) | |||
| No | 70.67 (59.71, 75.38) | 1.22 (0.93, 1.59) | 0.13 | ||
| Tumor deposit | |||||
| No | 82.70 (78.62, 88.54) | 1.0 (reference) | 1.0 (reference) | ||
| Yes | 69.90 (63.43, 74.71) | 1.46 (1.18, 1.80) | < 0.001 | 1.31 (1.08, 2.95) | 0.001 |
| Lymphovascular invasion | |||||
| No | 80.06 (77.17, 83.05) | 1.0 (reference) | 1.0 (reference) | ||
| Yes | 57.33 (47.80, 68.75) | 2.45 (1.63, 3.69) | < 0.001 | 1.50 (0.94, 2.41) | 0.08 |
| Perineural invasion | |||||
| No | 78.87 (76.02, 81.84) | 1.0 (reference) | 1.0 (reference) | ||
| Yes | 54.25 (41.00, 71.78) | 1.94 (1.48, 2.54) | < 0.001 | 1.60 (1.17, 2.19) | 0.002 |
| Postoperative CEA, ng/mL | |||||
| ≤ 5 | 88.59 (86.48, 91.73) | 1.0 (reference) | 1.0 (reference) | ||
| > 5 | 76.65 (69.83, 82.31) | 1.46 (1.18, 1.80) | < 0.001 | 1.49 (1.20, 1.85) | 0.01 |
| Postoperative CA19-9, ng/mL | |||||
| ≤ 37 | 85.64 (78.92, 89.93) | 1.0 (reference) | 1.0 (reference) | ||
| > 37 | 75.44 (70.65, 84.14) | 1.52 (1.19, 1.95) | 0.001 | 1.04 (0.91, 2.67) | 0.85 |
| New pathology N stage group | |||||
| Tumor deposit + lymph node metastases < 4 | 77.23 (73.81,79.60) | 1.0 (reference) | 1.0 (reference) | ||
| Lymph node metastases ≥ 4 | 62.30 (58.49, 68.11) | 1.94 (1.56, 2.42) | < 0.001 | 1.86 (1.49, 2.33) | 0.01 |
| Tumor deposit + lymph node metastases ≥ 4 | 61.42 (57.19, 65.13) | 1.98 (1.30, 3.00) | 0.001 | 1.88 (1.24, 2.87) | 0.003 |
APR abdominoperineal resection, BMI body mass index, CEA carcinoembryonic antigen, LR laparoscopic resection, OR open resection