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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Curr Opin Pharmacol. 2022 Mar 17;64:102204. doi: 10.1016/j.coph.2022.102204

Figure 1.

Figure 1.

Ultrastructural localization of hM4Di in monkeys, using the pre-embedding immunogold method to reveal the tag proteins mCherry (in A) or hemagglutinin (HA, B). A and B show electron micrographs of dendrites (d) in the amygdala of two monkeys, that received intra-amygdala injections of AAV5-hSyn-hM4Di-mCherry (A) or AAV5-hSyn-HA-hM4Di (B). The large majority of immunogold particles labeling hM4Di-mCherry are localized in the intracellular compartment (red arrowheads), while the gold particles labeling HA-hM4Di are bound to the plasma membrane (blue arrows). Scale bars: 0.6 μm (from Galvan et al 2019)