Table 1.
Anti-diabetic effects of UD Clinical Trial Studies
| Sample size and groups | UD dose and type of extract | Duration of study | outcome | References |
|---|---|---|---|---|
|
Intervention group (24 = 11 F + 13 M) control group (11 M + 10 F = 21) |
100 mg/kg capsule 3 portions a day -Hydroalcoholic extract |
8 weeks | Interleukin-6/ CRP↓ | [49] |
|
Intervention group (n = 27) control group (n = 23) |
100 mg/kg -Hydroalcoholic extract |
8 weeks |
TAC↑ SOD↑ No significant change in MDA and GPX |
[21] |
|
Intervention group (n = 46) control group (n = 46) |
one 500 mg capsule every 8 h | 3 months |
FBS↓ 2 h' postprandial glucose↓ HbA1c ↓ |
[50] |
|
1-aerobic training (Ae) (n = 10 M) 2- UD (n = 10 M) 3- (Ae + UD) (n = 10 M) 4-control group (n = 10 M) |
10 g of UD powder was dissolved in yogurt 15 min before breakfast | 8 weeks |
FBS↓ FBS was different in each of the 3 groups |
[50] |
|
1-aerobic training (Ae) (n = 10 F) 2-UD (n = 10 F) 3- (Ae + UD) (n = 10 F) 4-control group (n = 10 F) |
- | - | FBS↓, HDL-c ↓ | [51] |
|
Intervention (n = 25) control group (n = 24) |
100 mg/kg/day | 8 weeks | Insulin↑, FBS↓ | [52] |
|
Intervention group (n = 30) control group (n = 30) |
200 mg powder in a capsule per day | 90 days |
TG ↓ no effect on cholesterol and blood pressure |
[53] |
|
Intervention group (n = 25 F) control group (n = 25 F) |
5 ml UD 3 portions a day -hydro alcoholic extract |
8 weeks |
FPG and SGPT↓ HDL, NO and SOD ↑ |
[54] |
|
Intervention group (n = 24) control group (n = 21) |
100 mg per day -hydro alcoholic extract |
8 weeks |
TG, plasma atherogenic factors (LDL-C / HDL-C and Total Cholesterol / HDL-C) and SBP ↓, (HDL-C) ↑ No changes in DBP, TC and LDL-C |
[55] |
|
interval training [IT] (n = 10 M) [IT + UD] (n = 10 M) control group (n = 10 M) |
10 g UD powder 3 portions a day |
8 weeks | FBS↓, Blood pressure↓ | [56] |
|
Intervention group (n = 22) control group (n = 22) |
20 mg kg-1 day-1 -alcoholic extract |
8 weeks | blood glucose levels↓, AMPK and Insulin ↑ | [57] |
|
Intervention group (n = 25) control group (n = 25) |
100 mg kg-1 3 portions a day |
8 weeks | FBS and HbA1c↓ | [58] |
|
Intervention group (n = 42) control group (n = 44) |
500 mg capsule Every 8 h |
12 weeks | HbA1c↓ | [50] |
CRP, C-reactive protein; TAC, Total antioxidant activity; SOD,Superoxide dismutase; MDA, Malondialdehyde; GPX,Glutathione Peroxidase; FBS, Fasting Blood Sugar; HbA1c, Hemoglobin A1c.HDL-c, High-density lipoprotein-c; TG, triglyceride; NO, Nitric Oxide; SGPT, Serum glutamic pyruvic transaminase, SBP, Systolic blood pressureAMPK, AMP-activated protein kinase; DB, diastolic blood pressure; TC, Total Cholesterol.