Table 2.
Clinical and biochemical characteristics of the subjects according to KCNQ1 rs2237892 genotypes
| Parameter | CC | CT | P Value |
|---|---|---|---|
| Gender(Male/Female) | 26/56 | 6/12 | 0.893 |
| Age(Years) | 53.65 ± 0.78 | 52.87 ± 1.66 | 0.672 |
| Weight(Kg) - Baseline | 73.28 ± 1.07 | 72.58 ± 2.28 | 0.781 |
| Weight(Kg)-Posttreatment | 73.41 ± 1.09 | 72.98 ± 2.32 | 0.866 |
| ∆Weight(Kg) | 0.13 ± 0.14 | 0.40 ± 0.30 | 0.413 |
| BMI – Baseline(Kg/m2) | 27.83 ± 0.39 | 26.98 ± 0.84 | 0.365 |
| BMI – Posttreatment(Kg/m2) | 27.87 ± 0.40 | 27.14 ± 0.85 | 0.441 |
| ∆BMI(Kg/m2) | 0.04 ± 0.05 | 0.16 ± 0.11 | 0.344 |
| HbA1c – Baseline (%) | 8.64 ± 0.13 | 8.63 ± 0.28 | 0.976 |
| HbA1c – Posttreatment (%) | 7.67 ± 0.15 | 7.35 ± 0.32 | 0.379 |
| ∆HbA1c (%) | −0.97 ± 0.07 | −1.28 ± 0.15 | 0.064 |
| HDL-Baseline(mmol/L) | 1.15 ± 0.01 | 1.19 ± 0.04 | 0.369 |
| HDL-Posttreatment(mmol/L) | 1.13 ± 0.018 | 1.19 ± 0.03 | 0.167 |
| ∆HDL(mmol/L) | −0.011 ± 0.005 | 0.012 ± 0.01 | 0.061 |
| LDL-Baseline(mmol/L) | 2.99 ± 0.12 | 2.86 ± 0.26 | 0.657 |
| LDL-Posttreatment(mmol/L) | 2.55 ± 0.10 | 2.57 ± 0.21 | 0.927 |
| ∆LDL(mmol/L) | −0.42 ± 0.06 | −0.32 ± 0.14 | 0.527 |
| TG-Baseline(mmol/L) | 1.91 ± 0.05 | 1.83 ± 0.10 | 0.533 |
| TG-Posttreatment(mmol/L) | 1.85 ± 0.04 | 1.90 ± 0.10 | 0.628 |
| ∆TG(mmol/L) | −0.06 ± 0.02 | 0.05 ± 0.059 | 0.081 |
| TC-Baseline(mmol/L) | 4.60 ± 0.13 | 4.61 ± 0.29 | 0.969 |
| TC Posttreatment(mmol/L) | 4.44 ± 0.13 | 4.48 ± 0.29 | 0.907 |
| ∆TC(mmol/L) | −0.15 ± 0.08 | −0.13 ± 0.18 | 0.889 |
| FBS-Baseline(mmol/L) | 9.71 ± 0.14 | 10.02 ± 0.31 | 0.370 |
| FBS-Posttreatment(mmol/L) | 8.06 ± 0.16 | 7.77 ± 0.36 | 0.460 |
| ∆FBS(mmol/L) | −1.65 ± 0.10 | −2.11 ± 0.23 | 0.079 |
Data are presented as mean ± SEM. P < 0.05 compared CC vs. CT (ANOVA). All Values were adjusted for age, gender, BMI at baseline, and ∆ level adjusted for their baseline values (Comparison CC vs CT- Bonferroni test)