Table 2.
Paired assessment of patients with newly detectable TP53 mutation at time of relapse or refractory disease and of patients in remission at time of new TP53 mutation detection
| Paired assessment of patients with newly detectable TP53 mutation at baseline and at time of relapsed or refractory disease | |||||
| Patient a | p53 protein expression by IHC at baseline | Cytogenetics at baseline | p53 protein expression by IHC at relapse | Cytogenetics at relapse | TP53 VAF (%) |
| 1 | Wild-type pattern | Complex | Wild-type pattern | Complex | 5.5 |
| 2 | Mutant-high pattern | Complex | Mutant-high pattern | Complex | 95.6 |
| 3 | Mutant-low pattern | Other | Mutant-low pattern | Other | 16.7 |
| 4 | Mutant-low pattern | Other | Wild-type pattern | Diploid | 36.5 |
| 5 | Mutant-low pattern | Diploid | Mutant-high pattern | Complex | 43.3 |
| 6 | Wild-type pattern | Other | Mutant-low pattern | Other | 15.0 |
| 7 | Wild-type pattern | Diploid | Wild-type pattern | Diploid | 2.7 |
| 8 | n/a | Diploid | Mutant-high pattern | Complex | 19.1 |
| 9 | Wild-type pattern | Diploid | Mutant-high pattern | Complex | 19.9 |
| 10 | Wild-type pattern | Other | Mutant-low pattern | Diploid | 3.2 |
| 11 | Wild-type pattern | Other | Mutant-high pattern | Other | 1.1 |
| 12 | Wild-type pattern | Other | Mutant-high pattern | Other | 2.7 |
| 13 | Wild-type pattern | Other | Mutant-low pattern | Other | 9.3 |
| 14 | Wild-type pattern | Other | Mutant-low pattern | Diploid | 1.5 |
| 15 | Wild-type pattern | Diploid | Mutant-high pattern | Complex | 20.9 |
| 16 | Wild-type pattern | Other | n/a | Other | 1.1 |
| 17 | Wild-type pattern | Diploid | Mutant-low pattern | Complex | 1.4 |
| 18 | Mutant-low pattern | Complex | Mutant-high pattern | Complex | 95.2 |
| Paired assessment of patients at baseline and at time of new TP53 mutation detection while in remission | |||||
| Patient b | p53 protein expression by IHC at baseline | Cytogenetics at baseline | p53 protein expression by IHC at time of new TP53 mutation | Cytogenetics at time of new TP53 mutation | TP53 VAF (%) |
| 1 | Wild-type pattern | Diploid | Wild-type pattern | Diploid | 1.6 |
| 2 | Wild-type pattern | Diploid | Mutant-low pattern | Diploid | 5.7 |
| 3 | Wild-type pattern | Other | Wild-type pattern | Diploid | 1.0 |
| 4 | Wild-type pattern | Diploid | Mutant-low pattern | Diploid | 1.6 |
Abbreviations: IHC, immunhistochemistry; VAF, variant allelic frequency
a
11 patients did not have samples available for IHC at baseline or relapse/refractory disease
b
1 patient did not have samples available for IHC at baseline or at time of new TP53 mutation detection in remission