Table 4.

Meal effect on ghrelin secretion according sex and time

	Ghrelin (ng/ml)
Sexa
Men	− 0.30
	[− 0.75,0.16]
Timeb
60 min	− 0.56***
	[− 0.68,− 0.44]
120 min	− 0.70***
	[− 0.82,− 0.58]
180 min	− 0.58***
	[− 0.70,− 0.46]
Sex*time interactionc
Men*Time (60 min)	0.21*
	[0.04,0.38]
Men*time (120 min)	0.29***
	[0.12,0.45]
Men*time (180 min)	0.23**
	[0.06,0.39]
Interceptd
Constant	1.40***
	[1.08,1.72]

Values are coefficients obtained from mixed-effects linear regression models

To obtain the mean values of ghrelin over time, the coefficients shown in the table can be entered into the following sex-specific equations:

Women: constant + time (at a specific time point)

Men: constant + sex + time (at a specific time point) + interaction (at a specific time point)

^aThe effect of male sex on ghrelin at baseline. It represents how much the basal ghrelin concentration differed in men compared with women

^bThe effect of time on ghrelin concentration. It represents how much ghrelin concentration has changed over time from baseline in women

^cThe effect of male sex on ghrelin concentration over time. It represents how much the ghrelin changes from baseline in men differed from the changes observed in women over the same time frame

^dThe intercept represents the baseline ghrelin concentration in women

*p < 0.05, **p < 0.01, ***p < 0.001