Table 6.

Desensitization protocols for fluoroquinolones, vancomycin, tetracyclines, and macrolides

Drug class	Drug	Sample protocol	References
Fluoroquinolone	Ciprofloxacin	13 steps for cumulative dose of 450.55 mg: 0.05, 0.1, 0.2, 0.4, 0.8, 1.6, 3.2, 6.4, 12.8, 25, 50, 100, 250 mg in 15-min intervals	[32]
Vancomycin	Vancomycin	11 steps for goal cumulative dose (e.g., 1 g): 0.0060, 0.020, 0.060, 0.20, 0.60, 2.0, 6.0, 20, 60, 125 mg/hr in 15-min intervals, followed by 250 mg/hr for remainder of dosage	[12] Alternative rapid desensitization protocols: [69, 77] Slow desensitization protocols: [50, 139]
Tetracycline	Doxycycline	12 steps for a cumulative dose of 102 mg: 0.00001, 0.0001, 0.001, 0.01, 0.1, 1, 2, 4, 8, 12, 25, 50 mg in 30-min intervals	[113] Alternative protocols: [95, 114, 115]
	Minocycline	14 steps for cumulative dose of 140 mg: 0.01, 0.02, 0.04, 0.08, 0.16, 0.32, 0.64, 1.28, 2.56, 5, 10, 20, 40, 60 mg in 15 min intervals	[113]
	Tigecycline	12 steps for cumulative dose of 50 mg: 0.0010, 0.0025, 0.0050, 0.01, 0.025, 0.05, 0.1, 0.2, 0.4961, 0.9921, 1.9843 in 15 min intervals, followed by 46.134 mg over 186 min	[113]
Macrolide	Clarithromycin	14 steps for cumulative dose of 503 mg: 0.03, 0.06, 0.125, 0.25, 0.5, 1, 2, 4, 8, 16, 32, 64, 125, 250 mg in 15-min intervals	[136] Alternative protocols: [137]