Table 2. Comparison of HLA-A*11:01-restricted CTL epitopes and HLA-DRB1*15:01-restricted Th epitopes in Wuhan-Hu-1 S protein and Omicron S protein.
| HLA-A*11:01 CTL epitopes derived from S protein | Epitope rank in Wuhan-Hu-1† | Epitope mutation exist in Omicron | HLA-DRB1*15:01 Th Epitopes derived from S protein | Epitope rank in Wuhan-Hu-1§ | Epitope mutation exist in Omicron |
| Abbreviations: S=spike; HLA=human leukocyte antigen; CTL=cytotoxic T-lymphocytes; Th=T helper.† This rank is derived from the combined ranking of IEDB recommended 2020.09 and SYFPEITHI.§ This rank is derived from the combined ranking of IEDB recommended 2.22 and Propred. | |||||
| SVLNDILSR | 1 | L981F | PTESIVRFPNITNLC | 1 | No |
| GVYFASTEK | 2 | T95I | CSNLLLQYGSFCTQL | 2 | No |
| ASANLAATK | 2 | No | QPTESIVRFPNITNL | 2 | No |
| VTYVPAQEK | 3 | No | TESIVRFPNITNLCP | 2 | No |
| SSTASALGK | 4 | No | SNLLLQYGSFCTQLN | 3 | N764K |
| TLKSFTVEK | 5 | No | ECSNLLLQYGSFCTQ | 4 | No |
| GTHWFVTQR | 6 | No | ESIVRFPNITNLCPF | 4 | No |
| NSASFSTFK | 7 | S371L/S373P/S375F | NLLLQYGSFCTQLNR | 5 | N764K |
| GVLTESNKK | 8 | No | TECSNLLLQYGSFCT | 6 | No |
| GVYYHKNNK | 8 | No | LLLQYGSFCTQLNRA | 7 | N764K |
| QIYKTPPIK | 9 | No | LTDEMIAQYTSALLA | 8 | No |
| EILPVSMTK | 10 | No | DEMIAQYTSALLAGT | 9 | No |
| TDEMIAQYTSALLAG | 10 | No | |||