TABLE 1.
Summary of the demographic data collected from the 321 newborns of Qingdao cohort
| Type | Number | Percentage (%) | |
|---|---|---|---|
| Pregnancy | Natural pregnancy | 306 | 95.4 |
| Assisted reproduction technology | 11 | 3.4 | |
| Unspecified | 4 | 1.20 | |
| Gestational weeks | Pre‐term birth | 7 | 2.2 |
| Term birth | 314 | 97.80 | |
| Average delivery gestation | 39 weeks plus 5 days | – | |
| Gender of newborn | Male | 151 | 47.04 |
| Female | 170 | 52.96 | |
| Parental age at delivery | Father's age (ave. year) | 33 | – |
| Mother's age (ave. year) | 32 | – | |
| SD of father's age (year) | 5 | – | |
| SD of mother's age (year) | 4 | – | |
| Mandatory NBS screening of 4 metabolic diseases (PKU, CAH, CH and G6PD) by TRFIA | Phe + | 1 | 0.31 |
| Negative | 320 | 99.69 | |
| Mandatory hearing impairment screening by OAEs or AABR | Not passed | 0 | 0.00 |
| Passed | 321 | 100.00 | |
| 48 IMDs screening by tandem MS/MS | C5‐OH + | 1 | 0.31 |
| Phe + | 1 | 0.31 | |
| Negative | 310 | 96.57 | |
| Unspecified | 9 | 2.80 | |
| Genetic hearing loss screening by MALDI‐TOF | Carrier | 18 | 5.61 |
| Negative | 294 | 91.59 | |
| Unspecified | 9 | 2.80 |
AABR, automated auditory brainstem response; CAH, congenital adrenal hyperplasia; CH, congenital hypothyroidism; CH G6PD, glucose‐6‐phosphate dehydrogenase; C5‐OH+, isovalerylcarnitine positive; MS/MS, mass spectrometry; MALDI‐TOF, matrix‐assisted laser desorption/ionization time of flight; OAEs, otoacoustic emissions; PKU, phenylketonuria; Phe+, phenylalanine positive; SD, standard deviation; TRFIA, time resolved fluoroimmunoassay.