Table 4.
Adjusted relative risk ratio ratios (RRR, 95%CIs) for mild cognitive impairment and dementia according to the presence/absence of peripheral neuropathy (PN) overall and stratified by diabetes status, ARIC visit 6 (2016–2017)
| Mild Cognitive Impairment vs. Normal Cognition |
Dementia vs. Normal Cognition |
|||||
|---|---|---|---|---|---|---|
| N cases / N | RRR (95% CI) |
N cases / N | RRR (95% CI) |
|||
| Model 1 | Model 2 | Model 1 | Model 2 | |||
|
| ||||||
| Overall | ||||||
| No PN | 342/2044 | 1 (Ref) | 1 (Ref) | 79/2044 | 1 (Ref) | 1 (Ref) |
| With PN | 288/1318 | 1.37 (1.14–1.65) | 1.38 (1.14–1.67)* | 103/1318 | 1.85 (1.35–2.55) | 1.83 (1.32–2.55)* |
|
| ||||||
| No Diabetes | ||||||
| No PN | 236/1435 | 1 (Ref) | 1 (Ref) | 51/1435 | 1 (Ref) | 1 (Ref) |
| With PN | 189/856 | 1.38 (1.10–1.73) | 1.36 (1.08–1.72) | 70/856 | 1.95 (1.32–2.90) | 2.07 (1.37–3.12) |
|
| ||||||
| Diabetes | ||||||
| No PN | 106/609 | 1 (Ref) | 1 (Ref) | 28/609 | 1 (Ref) | 1 (Ref) |
| With PN | 99/462 | 1.34 (0.97–1.85) | 1.41 (1.02–1.97)** | 33/462 | 1.60 (0.93–2.74) | 1.38 (0.78–2.44)** |
Model 1: Adjusted for age, sex and race.
Model 2: Further adjusted for education, body mass index, smoking status, drinking status, diabetes status, cardiovascular disease, stroke, hypertension, hypercholesterolemia, cancer and APOE.
*
Model 2a = additionally adjusted for diabetes status
**
Model 2b = additionally adjusted for duration of diabetes (< 10 yrs vs. ≥ 10 yrs)