Table 1:
Joint analysis of NAT+AFR ancestry (EUR as reference). We also report the OR (CI) for the single-ancestry association analyses within blocks prioritized by the joint analyses. Index LA represents SNP with the top association statistics within those ancestral blocks.
| Ancestral block (Mb start – Mb end) |
Index LA | CHR | Joint Analysis p-value |
AFR | NAT | |||
|---|---|---|---|---|---|---|---|---|
| p-value | OR (95%CI) | p-value | OR (95%CI) | |||||
| Model 1 | 37.46 – 39.35 | 22:38647406 | 22 | 2.63E-06 | 3.94E-02 | 1.08 (1.00–1.15) | 2.78E-04 | 1.19 (1.10–1.29) |
| 23.10 – 25.35 | 21:23374870 | 21 | 4.64E-05 | 2.56E-01 | 0.95 (0.88–1.03) | 1.52E-03 | 0.84 (0.73–0.94) | |
| 45.21 – 47.34 | 19:47037620 | 19 | 7.03E-05 | 3.63E-02 | 1.07 (1.00–1.14) | 3.63E-02 | 1.12 (1.02 – 1.21) | |
| Model 2 | 37.42 – 39.47 | 22:38647406 | 22 | 3.30E-06 | 5.02E-02 | 1.07 (1.00–1.14) | 3.39E-04 | 1.19 (1.09–1.29) |
| 23.05 – 25.42 | 21:23374870 | 21 | 2.95E-05 | 2.16E-01 | 0.95 (0.88–1.02) | 1.09E-03 | 0.84 (0.73–0.94) | |
| 164.18 – 166.90 | 6:166240666 | 6 | 3.78E-05 | 2.05E-04 | 0.87 (0.80 – 0.94) | 9.32E-02 | 1.08 (0.98– 1.18) | |
| 111.58 – 113.75 | 1:112789288 | 1 | 1.11E-04 | 7.27E-03 | 1.10 (1.03–1.17) | 2.68E-02 | 1.11 (1.01– 1.20) | |
EUR =European ancestry, AFR = African ancestry, and NAT=Native American ancestry. OR= odds ratio. We report index LA in CHR:BP format, where CHR represents Chromosome and BP represents base-pair position (human genome hg19 build), respectively.